What is it?
Parabens are the most commonly used preservatives in cosmetics. They are also widely used in some medications, foods, and in industry.

Paraben mix contains the alkyl esters butyl-, ethyl-, methyl-, and propyl-paraben.

How can I avoid it?
Avoidance of parabens in cosmetics may be difficult since they are one of the most commonly used preservatives in the cosmetic industry.

Skin contact with parabens is required for it to cause a rash. Discontinuation of exposure to products containing parabens should result in improvement and/or resolution of your dermatitis. By law, all products made in the U.S. for topical use have ingredients listed either on
the product package or the box that contains it. Check the labeling of your skin care products for these ingredients. If there is not enough information, ask your pharmacist or retailer, or contact the company directly. At work, request a Safety Data Sheet (SDS) to help identify potential sources of exposure.

Because of the Paraben Paradox, patients who have a positive patch test reaction to parabens may still be able to tolerate cosmetics containing parabens. It is recommended that new cosmetics be tested on your skin before widespread application. You can test products
yourself by applying a small amount to a small area of skin on the forearm twice daily for a week and observing to see if a rash develops.  If no rash appears, the product is likely safe for you to use on your skin. Normal skin may tolerate exposure to small concentrates of parabens
in cosmetics.

The ingestion of paraben-containing foods does not seem to produce flares of dermatitis in paraben-sensitive individuals, especially if the lining of the mouth is intact. The FDA does not require the labeling of parabens in oral preparations and dentifrices. Therefore, it is difficult
to avoid contact.

Uses:
  • Medications
    • Antibiotics
    • Antiseptics
    • Antihypertensives
    • Antimicrobial and corticosteroid lotions/Creams/Ointments
    • Chemotherapeutic agents
    • Diuretics
    • Electrode jelly
    • Eye, ear, and nose drops
    • Heparin
    • Insulin
    • Local Anesthetics
    • Medicated dressing
    • Medicines
    • Rectal suspensions
    • Unna Boots
    • Vaginal jellies and suppositories
    • Vitamins
  • Foods
    • Candies
    • Frozen dairy products
    • Fruit juices
    • Jellies/Jams/Marmalades
    • Marinated fish products
    • Mayonnaise
    • Milk preparations
    • Mincemeat
    • Mustard
    • Packaged fish, meat and poultry
    • Pickles/Relishes
    • Processed vegetables
    • Salad dressing
    • Soft drinks
    • Some baked goods
    • Spiced sauces
    • Syrups
    • Tomato-based products (pulp, puree, ketchup)
  • Skin care products/Cosmetics
    • Deodorants
    • Hair sprays, gels, tonics, and lotions
    • Hair colorants/“Permanents-relaxers”
    • Soaps/Cleansers
    • Shampoos/Conditioners
    • Moisturizers
    • Make-up
    • Nail products
    • Nail polish remover
    • Powders/Sprays
    • Sunscreens/Bronzers
    • Wipes
    • Lipsticks and balms
    • Personal hygiene products
    • Soaps/Cleansers
    • Shaving products
  • Industrial
    • Metal-working oils
    • Fats
    • Glues
    • Shoe
    • Polish
    • Textiles
  • Others
    • Adhesives
    • Veterinary medications
    • Pet care products
    • Agriculture – food production and processing
Other names for butyl paraben:
  • 4-Hydroxybenzoic acid butyl ester
  • Aseptoform butyl
  • Benzoic acid, 4-hydroxy-, butyl ester
  • Benzoic acid, p-hydroxy-, butyl ester
  • Butoben
  • Butyl 4-hydroxybenzoate
  • Butyl butex
  • Butyl chemosept
  • Butyl p-hydroxybenzoate
  • Butyl parasept
  • Butyl tegosept
  • Butyl-Parasept
  • Butylparaben
  • n-Butyl hydroxybenzoate
  • n-Butyl p-hydroxybenzoate
  • n-Butyl parahydroxybenzoate
  • p-Hydroxybenzoic acid butyl ester
Other names for methyl paraben:
  • 4-(Methoxycarbonyl)phenol
  • 4-Hydroxybenzoic acid methyl ester
  • Benzoic acid, 4-hydroxy-, methyl ester
  • Benzoic acid, p-hydroxy-, methyl ester
  • Methyl 4-hydroxybenzoate
  • Methyl butex
  • Methyl ester of p-hydroxybenzoic acid
  • Methyl p-hydroxybenzoate
  • Methyl p-oxybenzoate
  • Methyl parahydroxybenzoate
  • Methyl parasept
  • Methylben
  • Methylparaben
  • p-Carbomethoxyphenol
  • p-Hydroxybenzoic acid methyl ester
  • p-Methoxycarbonylphenol
  • p-Oxybenzoesauremethylester
Other names for ethyl paraben:
  • 4-Hydroxybenzoic acid ethyl ester
  • Carbethoxyphenol
  • Ethyl 4-hydroxybenzoate
  • Ethyl butex
  • Ethyl p-hydroxybenzoate
  • Ethyl p-oxybenzoate
  • Ethyl parasept
  • Ethylparaben
  • p-Carbethoxyphenol
  • p-Hydroxybenzoic acid ethyl ester
Other names for propyl paraben:
  • 4-Hydroxybenzoic acid propyl ester
  • Benzoic acid, p-hydroxy-, propyl ester
  • N-Propyl p-hydroxybenzoate
  • Propyl 4-hydroxybenzoate
  • Propyl p-hydroxybenzoate
  • Propylparaben
  • Propylparasept
  • p-Hydroxypropyl benzoate
Potential cross-reacting/co-reacting substances:
  • Para-aminobenzoic acid (PABA) esters
  • Paraphenylenediamine (PPDA)
  • Other Parabens

MC4999-108(Rev 05-2025)

How safe is it?

Hang tight. We're thinking.